Osmosis Jones

Osmosis Jones
Theatrical release poster
Directed by	Bobby Farrelly Peter Farrelly
Written by	Marc Hyman
Produced by	Dennis Edwards Bobby Farrelly Peter Farrelly Zak Penn Bradley Thomas
Starring	Chris Rock Laurence Fishburne David Hyde Pierce Brandy Norwood William Shatner Molly Shannon Chris Elliott Bill Murray
Cinematography	Mark Irwin
Edited by	Lois Freeman-Fox Stephen Schaffer Sam Seig
Music by	Randy Edelman
Production companies	Warner Bros. Feature Animation Conundrum Entertainment
Distributed by	Warner Bros. Pictures
Release dates	August 7, 2001 (2001-08-07) (premiere) August 10, 2001 (2001-08-10) (United States)
Running time	95 minutes
Country	United States
Language	English
Budget	$70 million[1]
Box office	$14 million[2]

Osmosis Jones is a 2001 American live-action/animated buddy cop comedy film written by Marc Hyman. Combining live-action sequences directed by the Farrelly brothers and animation directed by Piet Kroon and Tom Sito, the film stars the voices of Chris Rock, Laurence Fishburne, David Hyde Pierce, Brandy Norwood, and William Shatner alongside Molly Shannon, Chris Elliott, and Bill Murray in live-action roles. It follows the title character, an anthropomorphic white blood cell, as he teams up with a cold pill to protect his unhealthy human host from a highly contagious virus called "the Red Death".

The film premiered on August 7, 2001, and was released theatrically three days later. It received mixed reviews from critics, who praised the world building, the animation, story, and voice performances, but criticized the inconsistent tone of the live-action portions and overuse of gross-out humor. The film was also a commercial failure, grossing $14 million worldwide against a $70 million budget. Despite the poor financial response, the film was followed by the animated television series Ozzy & Drix, which aired on Kids' WB for two seasons and 26 episodes from 2002 to 2004.

Frank DeTorre is an unkempt zookeeper at the Sucat Memorial Zoo in Rhode Island. He copes with his wife Maggie's death by overeating and foregoing basic hygiene, much to his daughter Shane's concern. Inside his body, white blood cell Osmosis "Ozzy" Jones is an overzealous officer of the "Frank Police Department," the body's center for responses against bodily threats.

Facing an election against Tom Colonic, Mayor Phlegmming doubles down on his junk food policies, so he could go to a food festival in Buffalo, New York, ignoring its effects on Frank's health. This causes Frank to eat a boiled egg covered in chimp saliva, allowing Thrax, a deadly virus known mainly as "The Red Death," to enter his body and inflame his throat. Phlegmming instructs Frank to take a cold pill. The pill, Special Agent Drixenol "Drix" Drixobenzometaphedramine, proceeds to disinfect the throat, covering up evidence of Thrax's arrival. Ozzy is told to assist Drix in his investigation, much to his displeasure. Thrax assumes leadership of a gang of sweat germs and breaks down Frank's mucus dam, nearly killing the duo and causing a runny nose. Ozzy tells Drix how he once caused Frank to vomit on Shane’s teacher Mrs. Boyd at a school science fair, which led to Frank's dismissal from his previous job and Mrs. Boyd filing a restraining order against him; Frank’s brother Bob had gotten him his job at the zoo and Ozzy was suspended for unnecessary force.

Ozzy and Drix visit Chill, a flu vaccine and an informant, who directs them to Thrax's hideout in a germ-ridden nightclub in a large zit on Frank's forehead. Ozzy goes undercover and infiltrates Thrax's gang, where he learns that Thrax intends to masquerade as a common cold and use his knowledge of DNA to kill Frank. When Ozzy is discovered, Drix comes to his aid, causing a brawl which culminates in the zit being popped by a grenade. The pus lands on Mrs. Boyd's lip during a meeting between her and Frank; in response, Phlegmming closes the investigation, dismisses Ozzy from the police force and orders Drix to leave Frank’s body. Back in the real world, Frank prepares to go to Buffalo, much to Shane's disapproval.

Unbeknownst to the duo, Thrax has survived the zit's destruction and launches a lone assault on the hypothalamus where he steals a crucial nucleotide. He then abducts Phlegmming's secretary, Leah Estrogen, and flees to the mouth to escape. His actions disable the body's ability to regulate temperature and Frank develops a dangerous fever. As Frank is hospitalized, Ozzy convinces Drix not to leave and the two catch up to Thrax and rescue Leah. Thrax induces Frank to sneeze him out of the mouth using pollen. Drix shoots Ozzy out of the mouth and he and Thrax both land on Shane's cornea. As the two battle, they end up on one of Shane's false eyelashes. Ozzy tricks Thrax into getting his hand embedded in the lash and escapes just as it falls into a beaker of rubbing alcohol, killing Thrax.

As Frank's temperature surpasses 108 °F (42 °C), he goes into cardiac arrest. Clinging onto one of Shane's tears as she mourns her father, Ozzy falls back into Frank's mouth with the stolen nucleotide, reviving him just in time. Ozzy is then welcomed back into the police force as he begins a relationship with Leah, and Drix stays as Ozzy's new partner, and Frank commits himself to living a healthier lifestyle. Phlegmming becomes a janitor in the bowels and is ejected from Frank’s body by flatulence after ignoring a notice not to push a button.

• Bill Murray as Francis "Frank" DeTorri, Shane's widowed father and Bob's brother, in whom Ozzy and his friends live.
• Molly Shannon as Mrs. Boyd, Shane's science and gym teacher.
• Chris Elliott as Robert "Bob" DeTorri, Frank's brother and Shane's uncle.
• Elena Franklin as Shane DeTorri, Frank's 10-year-old daughter and Bob's niece.
• Danny Murphy as the zookeeper superintendent
• Jack McCullough as a zookeeper

• Chris Rock as Osmosis "Ozzy" Jones, a quick-witted white blood cell with an impulsive personality.
• Laurence Fishburne as Thrax, a villainous and deadly virus who intends to gain infamy by killing Frank within 48 hours of infection.
• David Hyde Pierce as Special Agent Drixenol "Drix" Drixobenzometaphedramine, a by-the-book cold pill who becomes Ozzy's best friend and partner.
• Brandy Norwood as Leah Estrogen, Mayor Phlegmming's secretary and Ozzy's love interest.
• William Shatner as Mayor Phlegmming, the arrogant, incompetent and corrupt mayor of the City of Frank.
• Ron Howard as Tom Colonic, Phlegmming's rival for the mayor of the City of Frank who promotes good health for Frank in his campaign.

Twisted Brown Trucker members Kid Rock, Kenny Olsen, Jason Krause, Joe C., Stefanie Eulinberg, Jimmie "Bones" Trombly, and Uncle Kracker provide the voices of the fictional band "Kidney Rock".

Osmosis Jones went through development hell during production. The animated sequences, directed by Tom Sito and Piet Kroon, went into production as planned even being completed ahead of schedule, but acquiring both a director and a star actor for the live-action sequences took a considerable amount of time, until Bill Murray was cast as the main character of Frank, and Peter and Bobby Farrelly stepped in to direct the live-action sequences. As part of their contract, the Farrelly brothers are credited as the primary directors of the film, although they did no supervision of the animated portions of the film. Will Smith was interested in the part of Ozzy, but in the end, his schedule would not permit it.

Principal photography on the live-action scenes took place from April 2 to June 19, 2000, in Plymouth, Massachusetts.

Osmosis Jones was originally rated PG-13 by the MPAA for "crude language" and "bodily humor" in 2000. However, Warner Bros. edited the film to make it family-friendly; and in 2001 when it was released, the film was re-rated PG on appeal for "bodily humor".^{[citation needed]}

The first trailer for Osmosis Jones was released in front of Pokémon 3: The Movie on April 6, 2001, and contains a classical masterpiece from Stanley Kubrick's film 2001: A Space Odyssey.

Osmosis Jones was released on VHS and DVD on November 13, 2001 by Warner Home Video.

Osmosis Jones had its world premiere screening on August 7, 2001, at the Grauman's Egyptian Theatre before being widely released on August 10, 2001, in 2,305 theaters worldwide. Upon its original release, the film performed poorly, and was the penultimate project produced by Warner Bros. Feature Animation (preceded by The Iron Giant and followed by Looney Tunes: Back in Action, which both also failed at the box office upon their original releases). The film opened at #7 in its first opening weekend at the U.S. box office, accumulating $5,271,248 on its opening week. The film soon grossed $13,596,911.^[1] The film was a box office bomb, unable to recover its $70 million production budget.^[3]

On Rotten Tomatoes, Osmosis Jones has an approval rating of 56% based on 111 reviews, with an average rating of 5.5/10. The site's critical consensus reads, "The animated portion of Osmosis is zippy and fun, but the live-action portion is lethargic."^[4] On Metacritic, the film has a weighted average score of 57 out of 100, based on 28 critics, indicating "mixed or average reviews".^[5] Audiences polled by CinemaScore gave the film an average grade of "B−" on an A+ to F scale.^[6]

The animated parts of Osmosis Jones were praised for their plot and fast pace, in contrast with the criticized live-action segments. Robert Koehler of Variety praised the film for its animated and live-action segments intervening, claiming it to be "the most extensive interplay of live-action and animation since Who Framed Roger Rabbit".^[7] The New York Times wrote "the film, with its effluvia-festival brand of humor, is often fun, and the rounded, blobby rendering of the characters is likable. But the picture tries too hard to be offensive to all ages. I suspect that even the littlest viewers will be too old for that spit."^[8] Roger Ebert gave the film 3 out of 4 and wrote: "Likely to entertain kids, who seem to like jokes about anatomical plumbing. For adults, there is the exuberance of the animation and the energy of the whole movie, which is just plain clever."^[9]

The use of gross-out humor in the film's live-action sequences, as seen in most films directed by the Farrelly brothers, was widely criticized. As such, Lisa Alspector of the Chicago Reader described the film as a "cathartically disgusting adventure movie".^[10] Maitland McDonagh of TV Guide praised the film's animation and its glimpse of intelligence although did criticize the humor as being "so distasteful".^[11] Lisa Schwarzbaum of Entertainment Weekly felt that the film had a diverse premise as it "oscillates between streaky black comedy and sanitary instruction"; however the scatological themes were again pointed out.^[12] Jonathan Foreman of New York Post claimed Osmosis Jones to have generic plotting, saying that "It's no funnier than your average grade-school biology lesson and less pedagogically useful than your typical Farrelly brothers comedy."^[13] Michael Sragow of Baltimore Sun praised David Hyde Pierce's performance as Drix, claiming him to be "hilarious" and "a take-charge dose of medicine".^[14]

The film also received criticism for its use of the Kid Rock song "Cool Daddy, Cool", the full version of which has lyrics promoting statutory rape.^[15]

The film received numerous Annie Award nominations including Best Animated Feature (losing to Shrek).^[16]

A soundtrack containing hip hop and R&B music was released on August 7, 2001, by Atlantic Records. The soundtrack failed to chart on the Billboard 200, but Trick Daddy's single "Take It to da House" managed to make it to number 88 on the Billboard Hot 100 singles chart.

Ozzy & Drix, an animated series that serves as a stand-alone continuation of the film, starring Phil LaMarr and Jeff Bennett as the titular characters, aired on Kids' WB for two seasons and 26 episodes from September 14, 2002 to July 5, 2004.

• Once Upon a Time... Life, an animated series with similar anthropomorphic representations of cells and germs.
• Cells at Work!, a Japanese manga/anime series with a similar premise.
• Inner Workings, a Disney short film that is set in the human body.

Wikiquote has quotations related to Osmosis Jones.

• Osmosis Jones at IMDb