The plot of the novel Prey by Michael Crichton centers around self-replicating nanobots, which the protagonist attempts to stop before they evolve beyond control.
The video game series Tasty Planet revolves around nanotechnology designed as a cleaning product, which begins to self-replicate and consume everything on the planet.
The 1985 science fiction novel Blood Music features biological computers created from lymphocyte cells. Smuggled out of a laboratory, the cells multiply and evolve rapidly, eventually assimilating much of the biosphere of North America.
The Sonic the Hedgehog comic series included a 21-issue story arc known as the "Metal Virus Saga". The Metal Virus is depicted as a grey goo scenario that converts all organic life into machines. It replicates and mutates like a virus, turning sentient beings into zombie-like robots who spread the infection by touch.
The short story "Galactic North" by Alastair Reynolds features an interstellar cloud of von Neumann machines, referred to as "Greenfly". The Greenfly devours and converts all matter in its path, and is expected to eventually consume the universe.
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↑Dr Eric Drexler - Nanotechnology: The Big Picture
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↑ Vallero, Daniel (2007). Biomedical Ethics for Engineers: Ethics and Decision Making in Biomedical and Biosystem Engineering . Academic Press. ISBN9780080476100。