Missis Pongo - known as "Missis" to most. She is more intuitive but less practical than her husband, but just as famous and admired. She grasps the concepts of "magic" and "metaphysical" far better than her husband when the strange happenings occur.
The General - formerly "The Colonel" in the first novel, before his promotion, the Old English Sheepdog who lives at Tompkins farm next door to Pongo and Missis. He is able to communicate with his owner's son, Tommy Tompkins, in a half-dog half-human babble.
Cadpig - Pongo and Missis' twelfth-born and smallest puppy. As an adult, she accompanied Mr. Dearly to meet the Prime Minister and indicated she wished to stay at 10 Downing Street with him, becoming famous on TV speeches sitting next to her new master. She becomes Prime Minister during the crisis and is able to handle the situation with her parents' help and her own naturally "bossy" nature.
Cadpig's Cabinet - the dogs belonging to the Prime Minister's Cabinet, who take over their masters' jobs during the Crisis:
George, the Foreign Minister - a fat, clumsy but cosmopolitan Boxer. He and Roly Poly become good friends after realizing they are much alike, and together they take a short visit to Paris. He is named after Foreign Secretary George Brown.
Babs, Minister of Transport - a pretty brown Poodle, portrayed in the illustrations as a Standard Poodle, who is very fussy about traffic and crowds and is constantly making regulations. Gay and Lucky help her "dress up" and become her secretaries. She is named after Minister of Transport Barbara Castle.
Perdita and Prince - a married couple of liver-spotted Dalmatians, and the parents of eight of the stolen puppies from the first novel. They are left in charge of the Dearlys' household while Pongo and Missis go to London.
Roly Poly - a fat and accident-prone Dalmatian, one of Pongo and Missis' adult sons. He teaches George how to swim, and the two of them soon discover they have a lot in common and spend the day of magic visiting Paris together.
Patch - Pongo and Missis' son, who was the largest of the puppies and devoted to Cadpig. He refuses to marry as an adult because he does not want to pass on his patched-ear-and-eye fault. He is happily reunited with Cadpig and made her temporary Private Secretary in London.