A new Deadpoolongoing series written by Daniel Way with artist Paco Medina began as a Secret Invasion tie-in. In the first arc, the character is seen working with Nick Fury to steal data on how to kill the Skrull queen Veranke.[6][7]Norman Osborn steals the information that Deadpool had stolen from the Skrulls, and subsequent stories deal with the fallout from that. Writer Daniel Way explained, "the first thing Osborn does to try and take care of the situation is to bring in a hired gun to take Deadpool down, which would be Tiger-Shark. That would be the standard thing to do, but of course everything about Deadpool is non-standard. So it goes completely awry and Norman has to get more serious about things." The story also sees the return of Bob, Agent of Hydra, "I don't want the book to become 'Deadpool and Friends' so characters will drift in and out, but Bob was someone I definitely wanted to bring in. It just had to be at the perfect moment and when I was putting this storyline together that moment presented itself." This all led directly to a confrontation with the new Thunderbolts in "Magnum Opus" which crossed over between Deadpool vol. 2 #8–9 and Thunderbolts #130–131.[8]Thunderbolts writer Andy Diggle said, "it's a natural progression for Deadpool to go after Norman, and for Norman to send his personal hit-squad after Deadpool."[9] In Deadpool #15, Deadpool decides to become a hero resulting in conflicts with proper heroes like Spider-Man[10] (who he had recently encountered in The Amazing Spider-Man #611 as part of "The Gauntlet"[11]) and leading to a 3-issue arc where he takes on Hit-Monkey,[12] a character who debuted in the same month in a digital, then print, one-shot.[13][14]
A special anniversary issue titled Deadpool #900 was released in October 2009. It features stories written by several authors, with the main feature written by the original Deadpool series writer Joe Kelly and drawn by Deadpool's creator Rob Liefeld.
As part of Marvel's Marvel NOW! initiative a new Deadpool ongoing series was launched, written by Brian Posehn and Gerry Duggan and illustrated by Tony Moore.[15] In the 27th issue of his new series, as part of "All-New Marvel NOW!", Deadpool was married for the third time. Initially a secret, his bride was revealed in the web comic Deadpool: The Gauntlet to be Shiklah, Queen of the Undead. Deadpool also discovers that he has a daughter by the name of Eleanor "Ellie" Camacho from a former flame of Deadpool named Carmelita Camacho.[16]
Deadpool's death occurs in Deadpool #250 "The Death of Deadpool", involving story ideas that cowriters Gerry Duggan and Brian Posehn have had in mind since the beginning of the NOW series.[17] Issue #250 was technically issue #45 but was so named as it was the cumulative 250th issue of the character's solo series.[18] Deadpool faces off in a final showdown with ULTIMATUM and Flag-Smasher, killing all of them, and gives up the "Deadpool" identity, wishing to have a better life. He, along with his family and friends, (and presumably everyone on Earth) are all killed when the Earth collides with an alternate universe's Earth. Deadpool laments that the Secret Wars should have stayed an Avengers event, but then dies at peace, content that everybody else is dying with him.[19]
Volume 4
Deadpool Vol. 4 began in 2015, lasting for 36 issues and written by Gerry Duggan.
Volume 5: Despicable Deadpool
Deadpool Vol. 5 began in 2017, lasting for 14 issues. This Volume was subtitled Despicable Deadpool, was written by Gerry Duggan and included issue #300.
Volume 6
Deadpool Vol. 6 began in 2018, was written by Skottie Young and lasted for 15 issues.
Volume 7: King Deadpool
Deadpool Vol. 7 began in 2019, was written by Kelly Thompson and lasted for 10 issues.
Volume 8
Deadpool Vol. 8 began in 2022, was written by Alyssa Wong and lasted for 10 issues.
Volume 9
Deadpool Vol. 9 began in 2024, was written by Cody Ziglar and lasted for 15 issues. This volume included issue #350.