Choriogonadotropin subunit beta is a protein that in humans is encoded by the CGB7gene.[3][4]
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.[4]
References
123GRCh38: Ensembl release 89: ENSG00000196337–Ensembl, May 2017
↑"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (Nov 1983). "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". J Biol Chem. 258 (19): 11492–9. doi:10.1016/S0021-9258(17)44254-2. PMID6194155.
Human CGB7 genome location and CGB7 gene details page in the UCSC Genome Browser.
Further reading
Morgan FJ, Birken S, Canfield RE (1975). "The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit". J. Biol. Chem. 250 (13): 5247–58. doi:10.1016/S0021-9258(19)41303-3. PMID1150658.
Bo M、Boime I (1992) 「生体内における絨毛性ゴナドトロピンβ遺伝子クラスターの転写活性遺伝子の同定」J. Biol. Chem . 267 (5): 3179–84 . doi : 10.1016/S0021-9258(19)50712-8 . PMID 1371113 .