Lynette Cegelski

Lynette Cegelski is an American physical chemist and chemical biologist working to uncover and define the chemistry that underlies outstanding challenges in human health and sustainability. She is the Monroe E. Spaght Professor of Chemistry and, by courtesy, of chemical engineering at Stanford University.^[1] She is a Stanford Bio-X and Stanford ChEM-H affiliated faculty member.^[2]^[3]

Education

Cegelski studied chemistry at SUNY Binghamton in New York and graduated summa cum laude and a member of Phi Beta Kappa in 1998.^[2]^[4] She then worked in the lab of Jacob Schaefer at Washington University in St. Louis (WUSTL), earning a PhD in Chemistry in 2004.^[1]^[5]^[6] Her post-doctoral work was in the laboratory of Scott Hultgren in Molecular Microbiology and Infectious Diseases at the Washington University School of Medicine.^[1]

Research

Research in the Cegelski lab addresses pressing challenges in human health, sustainability, and the environment. The group's interdisciplinary work uses chemical tools to uncover how complex biological systems are built and controlled, from understanding bacterial cell walls and biofilms to discovering new molecular structures like phosphoethanolamine (pEtN) cellulose, and translating those insights into therapeutic and sustainable materials solutions.^[1]

Key Publications

Cegelski has authored or co-authored multiple publications that have been cited 100 or more times. As of January 2021, these include:

"The biology and future prospects of antivirulence therapies," Nature Reviews Microbiology.^[7]
"Morphological plasticity as a bacterial survival strategy," Nature Reviews Microbiology.^[8]
"Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation," Nature Chemical Biology.^[9]
"Conformation of microtubule-bound paclitaxel determined by fluorescence spectroscopy and REDOR NMR," Biochemistry.^[10]
"Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus," Journal of Molecular Biology.^[11]
"Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene," Science.^[12]
"Phosphoethanolamine cellulose: a naturally produced chemically modified cellulose," Science.^[13]

Awards

Cegelski's work has earned her several awards:

Presidential Early Career Award for Scientists and Engineers (PECASE)^[14]
Burroughs Wellcome Career Award at the Scientific Interface, for "Mapping the structural and functional landscape of the microbial extracellular matrix."^[15]
2010 NIH Director's New Innovator Award, for "Structure, Function, and Disruption of Microbial Amyloid Assembly and Biofilm Formation."^[16]
National Science Foundation CAREER Award, for "Form and Function of Bacterial Amyloid Fibers."^[17]

References

1 2 3 4"Lynette Cegelski | Department of Chemistry". chemistry.stanford.edu. Retrieved 2026-02-15.
1 2University, © Stanford; Stanford; California 94305 (2014-03-12). "Lynette Cegelski - Associate Professor of Chemistry". Welcome to Bio-X. Retrieved 2021-01-24.{{cite web}}: CS1 maint: numeric names: authors list (link)
↑"Lynette Cegelski | ChEM-H". chemh.stanford.edu. Retrieved 2021-01-24.
↑"PHI BETA KAPPA QUALIFIED LIST 1997". people.math.binghamton.edu. Retrieved 2021-01-24.
↑"Chemistry Tree - Lynette S. Cegelski". academictree.org. Retrieved 2021-01-24.
↑"Past Graduate Students | Jacob Schaefer Research Group | Washington University in St. Louis". sites.wustl.edu. Retrieved 2021-01-24.
↑Cegelski, Lynette; Marshall, Garland R.; Eldridge, Gary R.; Hultgren, Scott J. (Nov 2009). "Erratum: The biology and future prospects of antivirulence therapies". Nature Reviews Microbiology. 7 (11): 836. doi:10.1038/nrmicro2244. ISSN 1740-1526.
↑Justice, Sheryl S.; Hunstad, David A.; Cegelski, Lynette; Hultgren, Scott J. (Feb 2008). "Morphological plasticity as a bacterial survival strategy". Nature Reviews Microbiology. 6 (2): 162–168. doi:10.1038/nrmicro1820. ISSN 1740-1526. PMID 18157153. S2CID 7247384.
↑Cegelski, Lynette; Pinkner, Jerome S; Hammer, Neal D; Cusumano, Corinne K; Hung, Chia S; Chorell, Erik; Åberg, Veronica; Walker, Jennifer N; Seed, Patrick C; Almqvist, Fredrik; Chapman, Matthew R (2009-10-25). "Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation". Nature Chemical Biology. 5 (12): 913–919. doi:10.1038/nchembio.242. ISSN 1552-4450. PMC 2838449. PMID 19915538.
↑Li, Yankun; Poliks, Barbara; Cegelski, Lynette; Poliks, Mark; Gryczynski, Zygmunt; Piszczek, Grzegorz; Jagtap, Prakash G.; Studelska, Daniel R.; Kingston, David G. I.; Schaefer, Jacob; Bane, Susan (Jan 2000). "Conformation of Microtubule-Bound Paclitaxel Determined by Fluorescence Spectroscopy and REDOR NMR †". Biochemistry. 39 (2): 281–291. doi:10.1021/bi991936r. ISSN 0006-2960. PMID 10630987.
↑Kim, Sung Joon; Cegelski, Lynette; Stueber, Dirk; Singh, Manmilan; Dietrich, Evelyne; Tanaka, Kelly S.E.; Parr, Thomas R.; Far, Adel Rafai; Schaefer, Jacob (Mar 2008). "Oritavancin Exhibits Dual Mode of Action to Inhibit Cell-Wall Biosynthesis in Staphylococcus aureus". Journal of Molecular Biology. 377 (1): 281–293. doi:10.1016/j.jmb.2008.01.031. ISSN 0022-2836. PMC 2276640. PMID 18258256.
↑Chen, Zhixing; Mercer, Jaron A. M.; Zhu, Xiaolei; Romaniuk, Joseph A. H.; Pfattner, Raphael; Cegelski, Lynette; Martinez, Todd J.; Burns, Noah Z.; Xia, Yan (2017-08-04). "Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene". Science. 357 (6350): 475–479. Bibcode:2017Sci...357..475C. doi:10.1126/science.aan2797. ISSN 0036-8075. PMID 28774923.
↑Thongsomboon, Wiriya; Serra, Diego O.; Possling, Alexandra; Hadjineophytou, Chris; Hengge, Regine; Cegelski, Lynette (2018-01-19). "Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose". Science. 359 (6373): 334–338. Bibcode:2018Sci...359..334T. doi:10.1126/science.aao4096. ISSN 0036-8075. PMID 29348238.
↑"Twelve from Stanford honored with the Presidential Early Career Award for Scientists and Engineers | Department of Chemistry". chemistry.stanford.edu. 5 July 2019. Retrieved 2021-01-24.
↑"2012 Annual Report"(PDF). Burroughs Wellcome Fund. Retrieved 2021-01-24.
↑"NIH Director's New Innovator Award - Funded Research". commonfund.nih.gov. 26 June 2013. Retrieved 2021-01-24.
↑"NSF Award Search: Award#1453247 - CAREER: Form and Function of Bacterial Amyloid Fibers". www.nsf.gov. Retrieved 2021-01-24.

External links

Lab website
Lynette Cegelski publications indexed by Google Scholar

[stanford-1] 1 2 3 4"Lynette Cegelski | Department of Chemistry". chemistry.stanford.edu. Retrieved 2026-02-15.

[stanford2-2] 1 2University, © Stanford; Stanford; California 94305 (2014-03-12). "Lynette Cegelski - Associate Professor of Chemistry". Welcome to Bio-X. Retrieved 2021-01-24.{{cite web}}: CS1 maint: numeric names: authors list (link)

[3] "Lynette Cegelski | ChEM-H". chemh.stanford.edu. Retrieved 2021-01-24.

[4] "PHI BETA KAPPA QUALIFIED LIST 1997". people.math.binghamton.edu. Retrieved 2021-01-24.

[5] "Chemistry Tree - Lynette S. Cegelski". academictree.org. Retrieved 2021-01-24.

[6] "Past Graduate Students | Jacob Schaefer Research Group | Washington University in St. Louis". sites.wustl.edu. Retrieved 2021-01-24.

[7] Cegelski, Lynette; Marshall, Garland R.; Eldridge, Gary R.; Hultgren, Scott J. (Nov 2009). "Erratum: The biology and future prospects of antivirulence therapies". Nature Reviews Microbiology. 7 (11): 836. doi:10.1038/nrmicro2244. ISSN 1740-1526.

[8] Justice, Sheryl S.; Hunstad, David A.; Cegelski, Lynette; Hultgren, Scott J. (Feb 2008). "Morphological plasticity as a bacterial survival strategy". Nature Reviews Microbiology. 6 (2): 162–168. doi:10.1038/nrmicro1820. ISSN 1740-1526. PMID 18157153. S2CID 7247384.

[9] Cegelski, Lynette; Pinkner, Jerome S; Hammer, Neal D; Cusumano, Corinne K; Hung, Chia S; Chorell, Erik; Åberg, Veronica; Walker, Jennifer N; Seed, Patrick C; Almqvist, Fredrik; Chapman, Matthew R (2009-10-25). "Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation". Nature Chemical Biology. 5 (12): 913–919. doi:10.1038/nchembio.242. ISSN 1552-4450. PMC 2838449. PMID 19915538.

[10] Li, Yankun; Poliks, Barbara; Cegelski, Lynette; Poliks, Mark; Gryczynski, Zygmunt; Piszczek, Grzegorz; Jagtap, Prakash G.; Studelska, Daniel R.; Kingston, David G. I.; Schaefer, Jacob; Bane, Susan (Jan 2000). "Conformation of Microtubule-Bound Paclitaxel Determined by Fluorescence Spectroscopy and REDOR NMR †". Biochemistry. 39 (2): 281–291. doi:10.1021/bi991936r. ISSN 0006-2960. PMID 10630987.

[11] Kim, Sung Joon; Cegelski, Lynette; Stueber, Dirk; Singh, Manmilan; Dietrich, Evelyne; Tanaka, Kelly S.E.; Parr, Thomas R.; Far, Adel Rafai; Schaefer, Jacob (Mar 2008). "Oritavancin Exhibits Dual Mode of Action to Inhibit Cell-Wall Biosynthesis in Staphylococcus aureus". Journal of Molecular Biology. 377 (1): 281–293. doi:10.1016/j.jmb.2008.01.031. ISSN 0022-2836. PMC 2276640. PMID 18258256.

[12] Chen, Zhixing; Mercer, Jaron A. M.; Zhu, Xiaolei; Romaniuk, Joseph A. H.; Pfattner, Raphael; Cegelski, Lynette; Martinez, Todd J.; Burns, Noah Z.; Xia, Yan (2017-08-04). "Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene". Science. 357 (6350): 475–479. Bibcode:2017Sci...357..475C. doi:10.1126/science.aan2797. ISSN 0036-8075. PMID 28774923.

[13] Thongsomboon, Wiriya; Serra, Diego O.; Possling, Alexandra; Hadjineophytou, Chris; Hengge, Regine; Cegelski, Lynette (2018-01-19). "Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose". Science. 359 (6373): 334–338. Bibcode:2018Sci...359..334T. doi:10.1126/science.aao4096. ISSN 0036-8075. PMID 29348238.

[14] "Twelve from Stanford honored with the Presidential Early Career Award for Scientists and Engineers | Department of Chemistry". chemistry.stanford.edu. 5 July 2019. Retrieved 2021-01-24.

[15] "2012 Annual Report"(PDF). Burroughs Wellcome Fund. Retrieved 2021-01-24.

[16] "NIH Director's New Innovator Award - Funded Research". commonfund.nih.gov. 26 June 2013. Retrieved 2021-01-24.

[17] "NSF Award Search: Award#1453247 - CAREER: Form and Function of Bacterial Amyloid Fibers". www.nsf.gov. Retrieved 2021-01-24.

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Education

Research

Key Publications

Awards

References

External links

関連するトピック

American

physical chemist

chemical biologist

Professor