Robert J. Cotter

Robert J. Cotter
Born	(1943-07-15)July 15, 1943 Washington, D.C., U.S.
Died	November 12, 2012(2012-11-12) (aged 69)[1] Baltimore, Maryland, U.S.
Nationality	American
Alma mater	College of the Holy Cross (BS) Johns Hopkins University (PhD)
Known for	Time-of-flight mass spectrometry
Spouse	Catherine Clarke Fenselau
Awards	Field and Franklin Award (2011) ASMS Distinguished Contribution in Mass Spectrometry Award (2011)
Scientific career
Fields	Mass spectrometry
Institutions	Towson University Gettysburg College Johns Hopkins University
Doctoral advisor	W.S. Koski

Robert J. Cotter (July 15, 1943 – November 12, 2012) was an American chemist and mass spectrometrist. His research contributed to many early advances in the field of time-of-flight mass spectrometry. From 1998 to 2000 he was president of the American Society for Mass Spectrometry.^[2] Cotter was also a co-investigator on the Mars Organic Molecule Analyzer (MOMA) project, developing a miniaturized, low power consumption ion trap/time-of-flight mass spectrometer that was to be deployed with the ExoMars rover, now the Rosalind Franklin rover.^[3]

Cotter was raised in Abington, Massachusetts, and was the oldest of seven children. After being educated at Boston College High School in 1961, he attended the College of the Holy Cross in Worcester, Massachusetts. After graduating in 1965 with a Bachelor of Science (B.S.), he studied under W.S. Koski at Johns Hopkins University. He received his Ph.D. in 1972 and joined the faculty of Towson University and Gettysburg College.^[1]

From 1978 until his death in 2012, Robert Cotter was a member of the faculty at Johns Hopkins University in the departments of Pharmacology and Molecular Sciences and Biophysics and Biophysical Chemistry.^[4]

To increase the mass resolution in time-of-flight mass spectrometry, a reflectron is often employed. Traditional, single-stage or linear reflectrons suffered from a lack of sensitivity and resolving power when ion velocities (and thus kinetic energies were not equal. In MALDI mass spectrometry, metastable ions generated spontaneously after ionization (post-source decay) exhibit a wide spectrum of kinetic energies.^[5] This is also known to occur during collision-induced dissociation.^[6] In 1993, Cotter's research group discovered that, using a non-linear electric field, the spread of ion kinetic energies could be compensated, increasing the resolution of time-of-flight mass spectrometers and forming the basis for many modern TOF/TOF mass spectrometers.^[7]

While he is primarily known for his contributions to the field of time-of-flight mass spectrometry,^[8] his research in the development and application of new ionization techniques for complex biomolecules. These include thermal desorption,^[9] laser desorption,^[10] fast atom bombardment,^[11] thermospray^[12] and plasma desorption.^[13]

His research into ionization sources also enabled many other discoveries in biomedical sciences.^[6] In 1993, he was part of the research team responsible for implicating the 42 amino acid form of the protein Aβ in the pathology of Alzheimer's disease.^[14]

The Mars Organic Molecule Analyzer (MOMA) project is part of a collaboration to search for potential signatures of Martian life. Cotter was a deputy principal investigator and responsible for the design and development of a low-power, ion trap-time-of-flight mass spectrometer to be deployed with the ESA ExoMars rover.^[3] However, in February 2012, NASA cancelled its participation in the rover and defunded projects related to it.^[15] By November 2012 NASA reestablished the funding for the US part of MOMA.^[16]